ChemicalBook > CAS DataBase List > KO-947

KO-947

Product Name
KO-947
CAS No.
1695533-89-1
Chemical Name
KO-947
Synonyms
KO-947;KO947;KO-947;KO 947;6-benzyl-3-(pyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4,3-g]quinazolin-7(8H)-one;Inhibitor,ERK,KO-947,inhibit,KO 947,Extracellular signal regulated kinases,KO947;7H-Pyrazolo[4,3-g]quinazolin-7-one, 1,5,6,8-tetrahydro-6-(phenylmethyl)-3-(4-pyridinyl)-
CBNumber
CB63168747
Molecular Formula
C21H17N5O
Formula Weight
355.39
MOL File
1695533-89-1.mol
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KO-947 Property

Boiling point:
704.1±60.0 °C(Predicted)
Density 
1.354±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
DMSO:66.75(Max Conc. mg/mL);187.82(Max Conc. mM)
form 
A crystalline solid
pka
13.32±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29213
Product name
KO947
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
29213
Product name
KO947
Packaging
25mg
Price
$533
Updated
2024/03/01
Cayman Chemical
Product number
29213
Product name
KO947
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
29213
Product name
KO947
Packaging
10mg
Price
$243
Updated
2024/03/01
AK Scientific
Product number
8399EM
Product name
6-Benzyl-3-pyridin-4-yl-5,8-dihydro-1H-pyrazolo[4,3-g]quinazolin-7-one
Packaging
5mg
Price
$252
Updated
2021/12/16
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KO-947 Chemical Properties,Usage,Production

Description

KO947 is an ERK inhibitor (IC50 = <50 nM for ERK2). It is greater than 50-fold selective for ERK over a panel of 450 kinases. KO947 reduces phosphorylation of the ERK target p90 ribosomal S6 kinase (RSK) in A375 cancer cells containing constitutively active B-RAFV600E with an IC50 value of less than 250 nM. It inhibits proliferation of A375 cells, as well as mutant K-Ras-expressing HCT116 and H358 cancer cell lines (IC50s = 50-250 nM for all).

KO-947 Preparation Products And Raw materials

Raw materials

Preparation Products

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KO-947 Suppliers

China 59 United States 3 Global 62
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52927
Advantage
58

1695533-89-1, KO-947Related Search:


  • KO-947
  • 6-benzyl-3-(pyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4,3-g]quinazolin-7(8H)-one
  • KO947;KO-947;KO 947
  • 7H-Pyrazolo[4,3-g]quinazolin-7-one, 1,5,6,8-tetrahydro-6-(phenylmethyl)-3-(4-pyridinyl)-
  • Inhibitor,ERK,KO-947,inhibit,KO 947,Extracellular signal regulated kinases,KO947
  • 1695533-89-1